Correlation between Nod-like Receptor Protein 3 Inflammasome and Diabetic Dry Eye

Diabetes mellitus can cause a decrease in tear secretion and film composition, resulting series of pathological changes such as the stability film, increased risk inflammation, peripheral neuropathy impairment meibomian glands, leading to dry eye. The imbalance inflammatory mediators diabetic patients injury ocular surface are main factors that aggravate Nod-like receptor protein 3 inflammasome was related occurrence development various systemic diseases. Evaluate difference between nod-like eye parameters patients, analyze trend correlation discuss its mechanism. All subjects received teardrop break time, Schirmer’s I test, fluorescein staining score objective scatter index measurement. level 3, interleukin-1 beta, interleukin-6, interleukin-10, interleukin-18 tears meanwhile caspase-1, tumor necrosis factor alpha, interleukin-1β, interleukin-18, superoxide dismutase, monoamine oxidase type B serum measured by double antibody sandwich enzyme-linked immunosorbent assay. In addition, promoter gene expression levels toll-like 4, alpha were determined real-time quantitative real time polymerase chain reaction. BUT shortened, test scores reduced interleukin- 1β, interleukin-6 significantly while change interleukin-10 nonstatistical significance. decreased statistically, meanwhile, has no statistical difference. results reaction showed statistically also. Pearson analysis there strong positive significantly. There clinical eye, suggesting regulation may provide new ideas for preventing treating